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Below, we display that conolidine, a purely natural analgesic alkaloid used in conventional Chinese medication, targets ACKR3, thereby delivering supplemental evidence of the correlation involving ACKR3 and suffering modulation and opening substitute therapeutic avenues to the cure of Persistent
Conolidine is present in the bark on the tropical flowering shrub Tabernaemontana divaricata, usually called the pinwheel flower. The plant is native to southeast Asia, where it has extensive been used in regular Chinese, Ayurvedic and Thai medicines to deal with fever and agony.
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We demonstrated that, in contrast to classical opioid recep